Ontology highlight
ABSTRACT:
SUBMITTER: Mukherjee S
PROVIDER: S-EPMC5568992 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Mukherjee Shubhabrata S Russell Joshua C JC Carr Daniel T DT Burgess Jeremy D JD Allen Mariet M Serie Daniel J DJ Boehme Kevin L KL Kauwe John S K JSK Naj Adam C AC Fardo David W DW Dickson Dennis W DW Montine Thomas J TJ Ertekin-Taner Nilufer N Kaeberlein Matt R MR Crane Paul K PK
Alzheimer's & dementia : the journal of the Alzheimer's Association 20170224 10
<h4>Introduction</h4>We sought to determine whether a systems biology approach may identify novel late-onset Alzheimer's disease (LOAD) loci.<h4>Methods</h4>We performed gene-wide association analyses and integrated results with human protein-protein interaction data using network analyses. We performed functional validation on novel genes using a transgenic Caenorhabditis elegans Aβ proteotoxicity model and evaluated novel genes using brain expression data from people with LOAD and other neurod ...[more]