Ontology highlight
ABSTRACT:
SUBMITTER: Ono K
PROVIDER: S-EPMC5569050 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Ono Kentaro K Viet Chi T CT Ye Yi Y Dang Dongmin D Hitomi Suzuro S Toyono Takashi T Inenaga Kiyotoshi K Dolan John C JC Schmidt Brian L BL
Scientific reports 20170823 1
We propose a new mechanism of sensory modulation through cutaneous dopaminergic signalling. We hypothesize that dopaminergic signalling contributes to differential cutaneous sensitivity in darker versus lighter pigmented humans and mouse strains. We show that thermal and mechanical cutaneous sensitivity is pigmentation dependent. Meta-analyses in humans and mice, along with our own mouse behavioural studies, reveal higher thermal sensitivity in pigmented skin relative to less-pigmented or albino ...[more]