Ontology highlight
ABSTRACT:
SUBMITTER: Mugge FLB
PROVIDER: S-EPMC5569067 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Mügge Fernanda L B FLB Silva Aristóbolo M AM
Scientific reports 20170823 1
In response to ER stress, activating transcription factor 6 (ATF6) traffics from ER to Golgi apparatus where it is activated by cleavage before being translocated as transcription factor to the cell nucleus. In this work we describe ATF6α as a newly target of the aspirin metabolite sodium salicylate (NaSal). NaSal treatment of cells induces increases in ATF6α mRNA and protein levels, but these events are not accompanied by ATF6 activation. Conversely, NaSal inhibited ATF6 transactivating activit ...[more]