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Modeling human disease in rodents by CRISPR/Cas9 genome editing.

ABSTRACT: Modeling human disease has proven to be a challenge for the scientific community. For years, generating an animal model was complicated and restricted to very few species. With the rise of CRISPR/Cas9, it is now possible to generate more or less any animal model. In this review, we will show how this technology is and will change our way to obtain relevant disease animal models and how it should impact human health.

SUBMITTER: Birling MC

PROVIDER: S-EPMC5569124 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Modeling human disease in rodents by CRISPR/Cas9 genome editing.

Birling Marie-Christine MC Herault Yann Y Pavlovic Guillaume G

Mammalian genome : official journal of the International Mammalian Genome Society 20170704 7-8

Modeling human disease has proven to be a challenge for the scientific community. For years, generating an animal model was complicated and restricted to very few species. With the rise of CRISPR/Cas9, it is now possible to generate more or less any animal model. In this review, we will show how this technology is and will change our way to obtain relevant disease animal models and how it should impact human health. ...[more]

PMID: 28677007

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