Randomized supplementation of 4000 IU vitamin D₃ daily vs placebo on the prevalence of anemia in advanced heart failure: the EVITA trial.

ABSTRACT:

Background

Low 25-hydroxyvitamin D (25OHD) levels (< 75 nmol/l) are inversely associated with anemia prevalence. Since anemia and low 25OHD levels are common in patients with heart failure (HF), we aimed to investigate whether vitamin D supplementation can reduce anemia prevalence in advanced HF.

Methods

EVITA (Effect of Vitamin D on Mortality in Heart Failure) is a randomized, placebo-controlled clinical trial in patients with initial 25OHD levels < 75 nmol/l. Participants received either 4000 IU vitamin D₃ daily or a matching placebo for 36 months. A total of 172 patients (vitamin D group: n = 85; placebo group: n = 87) were investigated in this pre-specified secondary data analysis. Hemoglobin (Hb) and other hematological parameters were measured at baseline an

SUBMITTER: Ernst JB 

PROVIDER: S-EPMC5569566 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature