Ontology highlight
ABSTRACT:
SUBMITTER: Lee PW
PROVIDER: S-EPMC5569573 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20170125 9
Covalent conjugation of water-soluble polymers to proteins is critical for evading immune surveillance in the field of biopharmaceuticals. The most common and long-standing polymer modification is the attachment of methoxypoly(ethylene glycol) (mPEG), termed PEGylation, which has led to several clinically approved pharmaceuticals. Recent data indicate that brush-type polymers significantly enhance in vitro and in vivo properties. Herein, the polymer conformation of poly(ethylene glycol) is detai ...[more]