Ontology highlight
ABSTRACT:
SUBMITTER: Michelassi F
PROVIDER: S-EPMC5569903 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Michelassi Francesco F Liu Haowen H Hu Zhitao Z Dittman Jeremy S JS
Neuron 20170801 3
Almost all known forms of fast chemical synaptic transmission require the synaptic hub protein Munc13. This essential protein has also been implicated in mediating several forms of use-dependent plasticity, but the mechanisms by which it controls vesicle fusion and plasticity are not well understood. Using the C. elegans Munc13 ortholog UNC-13, we show that deletion of the C2B domain, the most highly conserved domain of Munc13, enhances calcium-dependent exocytosis downstream of vesicle priming, ...[more]