Ontology highlight
ABSTRACT:
SUBMITTER: Fijalkowska D
PROVIDER: S-EPMC5570006 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Fijalkowska Daria D Verbruggen Steven S Ndah Elvis E Jonckheere Veronique V Menschaert Gerben G Van Damme Petra P
Nucleic acids research 20170701 13
Alternative translation initiation mechanisms such as leaky scanning and reinitiation potentiate the polycistronic nature of human transcripts. By allowing for reprogrammed translation, these mechanisms can mediate biological responses to stimuli. We combined proteomics with ribosome profiling and mRNA sequencing to identify the biological targets of translation control triggered by the eukaryotic translation initiation factor 1 (eIF1), a protein implicated in the stringency of start codon selec ...[more]