Ontology highlight
ABSTRACT:
SUBMITTER: Sinturel F
PROVIDER: S-EPMC5570523 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Sinturel Flore F Gerber Alan A Mauvoisin Daniel D Wang Jingkui J Gatfield David D Stubblefield Jeremy J JJ Green Carla B CB Gachon Frédéric F Schibler Ueli U
Cell 20170501 4
The liver plays a pivotal role in metabolism and xenobiotic detoxification, processes that must be particularly efficient when animals are active and feed. A major question is how the liver adapts to these diurnal changes in physiology. Here, we show that, in mice, liver mass, hepatocyte size, and protein levels follow a daily rhythm, whose amplitude depends on both feeding-fasting and light-dark cycles. Correlative evidence suggests that the daily oscillation in global protein accumulation depe ...[more]