Ontology highlight
ABSTRACT:
SUBMITTER: Brownstein AJ
PROVIDER: S-EPMC5570562 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Brownstein Adam J AJ Ziganshin Bulat A BA Kuivaniemi Helena H Body Simon C SC Bale Allen E AE Elefteriades John A JA
Aorta (Stamford, Conn.) 20170201 1
Thoracic aortic aneurysm (TAA) is a lethal disease, with a natural history of enlarging progressively until dissection or rupture occurs. Since the discovery almost 20 years ago that ascending TAAs are highly familial, our understanding of the genetics of thoracic aortic aneurysm and dissection (TAAD) has increased exponentially. At least 29 genes have been shown to be associated with the development of TAAD, the majority of which encode proteins involved in the extracellular matrix, smooth musc ...[more]