NFATc2 enhances tumor-initiating phenotypes through the NFATc2/SOX2/ALDH axis in lung adenocarcinoma.
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ABSTRACT:
SUBMITTER: Xiao ZJ
PROVIDER: S-EPMC5570574 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
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NFATc2 enhances tumor-initiating phenotypes through the NFATc2/SOX2/ALDH axis in lung adenocarcinoma.
Xiao Zhi-Jie ZJ Liu Jing J Wang Si-Qi SQ Zhu Yun Y Gao Xu-Yuan XY Tin Vicky Pui-Chi VP Qin Jing J Wang Jun-Wen JW Wong Maria Pik MP
eLife 20170724
Tumor-initiating cells (TIC) are dynamic cancer cell subsets that display enhanced tumor functions and resilience to treatment but the mechanism of TIC induction or maintenance in lung cancer is not fully understood. In this study, we show the calcium pathway transcription factor NFATc2 is a novel regulator of lung TIC phenotypes, including tumorspheres, cell motility, tumorigenesis, as well as in vitro and in vivo responses to chemotherapy and targeted therapy. In human lung cancers, high NFATc ...[more]
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