Dataset Information

Differential item functioning in the Unified Dyskinesia Rating Scale (UDysRS).

ABSTRACT: Test if differential item functioning due to gender, age, race/ethnicity, or education impacts Unified Dyskinesia Rating Scale scores.Testing rating scales for differential item functioning is a core validation step. If differential item functioning exists, interpretation of item scores must consider secondary influences on dyskinesia ratings.Using Unified Dyskinesia Rating Scale translation databases (N?=?3,132), we tested uniform and nonuniform differential item functioning. We required confirmation by two independent methods and considered differential item functioning pertinent if McFadden pseudo R2 magnitude statistics exceeded negligible ratings.No age, race/ethnicity, or education nonuniform differential item functioning was identified. Gender nonuniform differential item functioning occurred for 2 items, both with negligible magnitude. Gender, race, and education uniform differential item functioning was observed for multiple items, all with negligible magnitude.The Unified Dyskinesia Rating Scale items effectively capture dyskinesia severity without pertinent gender, age, race/ ethnicity, or education influence. © 2017 International Parkinson and Movement Disorder Society.

SUBMITTER: Luo S

PROVIDER: S-EPMC5570621 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Differential item functioning in the Unified Dyskinesia Rating Scale (UDysRS).

Luo Sheng S Liu Yuanyuan Y Teresi Jeanne A JA Stebbins Glenn T GT Goetz Christopher G CG

Movement disorders : official journal of the Movement Disorder Society 20170601 8

<h4>Objective</h4>Test if differential item functioning due to gender, age, race/ethnicity, or education impacts Unified Dyskinesia Rating Scale scores.<h4>Background</h4>Testing rating scales for differential item functioning is a core validation step. If differential item functioning exists, interpretation of item scores must consider secondary influences on dyskinesia ratings.<h4>Methods</h4>Using Unified Dyskinesia Rating Scale translation databases (N = 3,132), we tested uniform and nonunif ...[more]

PMID: 28568607

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Project description:BackgroundAlthough nontremor and tremor Part 3 Movement Disorder Society-Unified Parkinson's Disease Rating Scale items measure different impairment domains, their distinct progression and drug responsivity remain unstudied longitudinally. The total score may obscure important time-based and treatment-based changes occurring in the individual domains.ObjectiveUsing the unique advantages of item response theory (IRT), we developed novel longitudinal unidimensional and multidimensional models to investigate nontremor and tremor changes occurring in an interventional Parkinson's disease (PD) study.MethodWith unidimensional longitudinal IRT, we assessed the 33 Part 3 item data (22 nontremor and 10 tremor items) of 336 patients with early PD from the STEADY-PD III (Safety, Tolerability, and Efficacy Assessment of Isradipine for PD, placebo vs. isradipine) study. With multidimensional longitudinal IRT, we assessed the progression rates over time and treatment (in overall motor severity, nontremor, and tremor domains) using Markov Chain Monte Carlo implemented in Stan.ResultsRegardless of treatment, patients showed significant but different time-based deterioration rates for total motor, nontremor, and tremor scores. Isradipine was associated with additional significant deterioration over placebo in total score and nontremor scores, but not in tremor score. Further highlighting the 2 separate latent domains, nontremor and tremor severity changes were positively but weakly correlated (correlation coefficient, 0.108).ConclusionsLongitudinal IRT analysis is a novel statistical method highly applicable to PD clinical trials. It addresses limitations of traditional linear regression approaches and previous IRT investigations that either applied cross-sectional IRT models to longitudinal data or failed to estimate all parameters simultaneously. It is particularly useful because it can separate nontremor and tremor changes both over time and in response to treatment interventions.

Dataset Information

Differential item functioning in the Unified Dyskinesia Rating Scale (UDysRS).

Publications

Differential item functioning in the Unified Dyskinesia Rating Scale (UDysRS).

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