Ontology highlight
ABSTRACT:
SUBMITTER: Shao Y
PROVIDER: S-EPMC5570943 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Shao Yiming Y Chen Feng F Chen Yuhua Y Zhang Wenying W Lin Yao Y Cai Yujie Y Yin Zihan Z Tao Shoubao S Liao Qinghui Q Zhao Jianghao J Mai Hui H He Yanfang Y He Junbing J Cui Lili L
Scientific reports 20170824 1
Previous studies demonstrated significant roles of autophagy in the pathogenesis of sepsis, but few studies focused on the effect of autophagy-related SNPs on sepsis susceptibility. In this present study, five polymorphisms of ATG5/ATG16L1 were investigated for the possible risk on sepsis in a Chinese Han population. Our results showed that ATG5 expression levels decreased with the severity of sepsis, and rs506027 T > C and rs510432 G > A were associated with sepsis progression and mortality. Mo ...[more]