Ontology highlight
ABSTRACT:
SUBMITTER: Moritz KE
PROVIDER: S-EPMC5571106 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Moritz Kasey E KE McCormack Nikki M NM Abera Mahlet B MB Viollet Coralie C Yauger Young J YJ Sukumar Gauthaman G Dalgard Clifton L CL Burnett Barrington G BG
Scientific reports 20170824 1
Microglia regulate the brain microenvironment by sensing damage and neutralizing potentially harmful insults. Disruption of central nervous system (CNS) homeostasis results in transition of microglia to a reactive state characterized by morphological changes and production of cytokines to prevent further damage to CNS tissue. Immunoproteasome levels are elevated in activated microglia in models of stroke, infection and traumatic brain injury, though the exact role of the immunoproteasome in neur ...[more]