Ontology highlight
ABSTRACT:
SUBMITTER: Kim TS
PROVIDER: S-EPMC5571369 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20170824 9
<i>Mycobacterium abscessus</i> is a highly pathogenic drug-resistant rapidly growing mycobacterium. In this study, we evaluated the <i>in vitro</i>, intracellular, and <i>in vivo</i> activities of LCB01-0371, a novel and safe oxazolidinone derivative, for the treatment of <i>M. abscessus</i> infection and compared its resistance to that of other oxazolidinone drugs. LCB01-0371 was effective against several <i>M. abscessus</i> strains <i>in vitro</i> and in a macrophage model of infection. In the ...[more]