Unknown

Dataset Information

0

Genetics of generalized anxiety disorder and related traits.


ABSTRACT: This review serves as a systematic guide to the genetics of generalized anxiety disorder (GAD) and further focuses on anxiety-relevant endophenotypes, such as pathological worry fear of uncertainty, and neuroticism. We inspect clinical genetic evidence for the familialityl heritability of GAD and cross-disorder phenotypes based on family and twin studies. Recent advances of linkage studies, genome-wide association studies, and candidate gene studies (eg, 5-HTT, 5-HT1A, MAOA, BDNF) are outlined. Functional and structural neuroimaging and neurophysiological readouts relating to peripheral stress markers and psychophysiology are further integrated, building a multilevel disease framework. We explore etiologic factors in gene-environment interaction approaches investigating childhood trauma, environmental adversity, and stressful life events in relation to selected candidate genes (5-HTT, NPSR1, COMT, MAOA, CRHR1, RGS2), Additionally, the pharmacogenetics of selective serotonin reuptake inhibitor/serotonin-norepinephrine reuptake inhibitor treatment are summarized (5-HTT, 5-HT2A, COMT, CRHR1). Finally, GAD and trait anxiety research challenges and perspectives in the field of genetics, including epigenetics, are discussed.

SUBMITTER: Gottschalk MG 

PROVIDER: S-EPMC5573560 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

altmetric image

Publications

Genetics of generalized anxiety disorder and related traits.

Gottschalk Michael G MG   Domschke Katharina K  

Dialogues in clinical neuroscience 20170601 2


This review serves as a systematic guide to the genetics of generalized anxiety disorder (GAD) and further focuses on anxiety-relevant endophenotypes, such as pathological worry fear of uncertainty, and neuroticism. We inspect clinical genetic evidence for the familialityl heritability of GAD and cross-disorder phenotypes based on family and twin studies. Recent advances of linkage studies, genome-wide association studies, and candidate gene studies (eg, <i>5-HTT, 5-HT1A, MAOA, BDNF</i>) are out  ...[more]

Similar Datasets

| S-EPMC5349709 | biostudies-literature
2014-12-01 | GSE61672 | GEO
| S-EPMC7541941 | biostudies-literature
| S-EPMC7357573 | biostudies-literature
| S-EPMC4973631 | biostudies-literature
| S-EPMC7466835 | biostudies-literature
| S-EPMC3424322 | biostudies-literature
| S-EPMC5302105 | biostudies-literature
| S-EPMC5515235 | biostudies-literature
| S-EPMC7198974 | biostudies-literature