Ontology highlight
ABSTRACT:
SUBMITTER: Strickland SA
PROVIDER: S-EPMC5573653 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Strickland Stephen A SA Sun Zhuoxin Z Ketterling Rhett P RP Cherry Athena M AM Cripe Larry D LD Dewald Gordon G Fernandez Hugo F HF Hicks Gary A GA Higgins Rodney R RR Lazarus Hillard M HM Litzow Mark R MR Luger Selina M SM Paietta Elisabeth M EM Rowe Jacob M JM Vance Gail H GH Wiernik Peter P Wiktor Anne E AE Zhang Yanming Y Tallman Martin S MS
Leukemia research 20170512
The presence of a monosomal karyotype (MK+) and/or a complex karyotype (CK+) identifies subcategories of AML with poor prognosis. The prognostic significance of the most common monosomies (monosomy 5, monosomy 7, and monosomy 17) within MK+/CK+AML is not well defined. We analyzed data from 1,592 AML patients age 17-93 years enrolled on ECOG-ACRIN therapeutic trials. The majority of MK+ patients (182/195; 93%) were MK+/CK+ with 87% (158/182) having ≥5 clonal abnormalities (CK≥5). MK+ patients wit ...[more]