Ontology highlight
ABSTRACT:
SUBMITTER: Cohn AL
PROVIDER: S-EPMC5573752 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Cohn Allen Lee AL Yoshino Takayuki T Heinemann Volker V Obermannova Radka R Bodoky György G Prausová Jana J Garcia-Carbonero Rocio R Ciuleanu Tudor T Garcia-Alfonso Pilar P Portnoy David C DC Van Cutsem Eric E Yamazaki Kentaro K Clingan Philip R PR Polikoff Jonathon J Lonardi Sara S O'Brien Lisa M LM Gao Ling L Yang Ling L Ferry David D Nasroulah Federico F Tabernero Josep J
Cancer chemotherapy and pharmacology 20170725 3
<h4>Purpose</h4>To characterize ramucirumab exposure-response relationships for efficacy and safety in patients with metastatic colorectal cancer (mCRC) using data from the RAISE study.<h4>Methods</h4>Sparse pharmacokinetic samples were collected; a population pharmacokinetic analysis was conducted. Univariate and multivariate Cox proportional hazards models analyzed the relationship between predicted ramucirumab minimum trough concentration at steady state (C <sub>min,ss</sub>) and survival. Ka ...[more]