Ontology highlight
ABSTRACT: Conclusion
The combination of GLE and PIB was highly efficacious and well tolerated in patients with HCV genotype 1 infection and prior failure of DAA-containing therapy; RBV coadministration did not improve efficacy. (Hepatology 2017;66:389-397).
SUBMITTER: Poordad F
PROVIDER: S-EPMC5573922 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Poordad Fred F Felizarta Franco F Asatryan Armen A Sulkowski Mark S MS Reindollar Robert W RW Landis Charles S CS Gordon Stuart C SC Flamm Steven L SL Fried Michael W MW Bernstein David E DE Lin Chih-Wei CW Liu Ran R Lovell Sandra S SS Ng Teresa I TI Kort Jens J Mensa Federico J FJ
Hepatology (Baltimore, Md.) 20170410 2
Although direct-acting antiviral (DAA) therapies for chronic hepatitis C virus (HCV) infection have demonstrated high rates of sustained virologic response, virologic failure may still occur, potentially leading to the emergence of viral resistance, which can decrease the effectiveness of subsequent treatment. Treatment options for patients who failed previous DAA-containing regimens, particularly those with nonstructural protein 5A inhibitors, are limited and remain an area of unmet medical nee ...[more]