Ontology highlight
ABSTRACT:
SUBMITTER: Haworth JA
PROVIDER: S-EPMC5574023 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Haworth Jennifer A JA Jenkinson Howard F HF Petersen Helen J HJ Back Catherine R CR Brittan Jane L JL Kerrigan Steve W SW Nobbs Angela H AH
Cellular microbiology 20161011 1
A range of Streptococcus bacteria are able to interact with blood platelets to form a thrombus (clot). Streptococcus gordonii is ubiquitous within the human oral cavity and amongst the common pathogens isolated from subjects with infective endocarditis. Two cell surface proteins, Hsa and Platelet adherence protein A (PadA), in S. gordonii mediate adherence and activation of platelets. In this study, we demonstrate that PadA binds activated platelets and that an NGR (Asparagine-Glycine-Arginine) ...[more]