Adipose tissue macrophages develop from bone marrow-independent progenitors in Xenopus laevis and mouse.
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ABSTRACT:
SUBMITTER: Hassnain Waqas SF
PROVIDER: S-EPMC5574031 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Publications
Adipose tissue macrophages develop from bone marrow-independent progenitors in <i>Xenopus laevis</i> and mouse.
Hassnain Waqas Syed F SF Noble Anna A Hoang Anh C AC Ampem Grace G Popp Manuela M Strauß Sarah S Guille Matthew M Röszer Tamás T
Journal of leukocyte biology 20170622 3
ATMs have a metabolic impact in mammals as they contribute to metabolically harmful AT inflammation. The control of the ATM number may have therapeutic potential; however, information on ATM ontogeny is scarce. Whereas it is thought that ATMs develop from circulating monocytes, various tissue-resident Mϕs are capable of self-renewal and develop from BM-independent progenitors without a monocyte intermediate. Here, we show that amphibian AT contains self-renewing ATMs that populate the AT before ...[more]
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