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CD271 determines migratory properties of melanoma cells.


ABSTRACT: Melanoma cell expression of the nerve growth factor receptor CD271 is associated with stem-like properties. However, the contributing role of the receptor in melanoma cell migration is elusive. Here, we explored extracranial (skin, soft tissue, lymph node and liver, n?=?13) and matched brain metastases (BM, n?=?12) and observed a heterogeneous distribution of phenotypically distinct subsets of CD271+ cells. In addition, we observed that CD271 expression gradually rises along with melanoma progression and metastasis by exploration of publicly available expression data of nevi, primary melanoma (n?=?31) and melanoma metastases (n?=?54). Furthermore, we observed highest levels of CD271 in BM. Sub-clustering identified 99 genes differentially expressed among CD271high and CD271low (p?

SUBMITTER: Radke J 

PROVIDER: S-EPMC5574914 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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CD271 determines migratory properties of melanoma cells.

Radke Josefine J   Roßner Florian F   Redmer Torben T  

Scientific reports 20170829 1


Melanoma cell expression of the nerve growth factor receptor CD271 is associated with stem-like properties. However, the contributing role of the receptor in melanoma cell migration is elusive. Here, we explored extracranial (skin, soft tissue, lymph node and liver, n = 13) and matched brain metastases (BM, n = 12) and observed a heterogeneous distribution of phenotypically distinct subsets of CD271<sup>+</sup> cells. In addition, we observed that CD271 expression gradually rises along with mela  ...[more]

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