Ontology highlight
ABSTRACT:
SUBMITTER: Asim M
PROVIDER: S-EPMC5575038 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Asim Mohammad M Tarish Firas F Zecchini Heather I HI Sanjiv Kumar K Gelali Eleni E Massie Charles E CE Baridi Ajoeb A Warren Anne Y AY Zhao Wanfeng W Ogris Christoph C McDuffus Leigh-Anne LA Mascalchi Patrice P Shaw Greg G Dev Harveer H Wadhwa Karan K Wijnhoven Paul P Forment Josep V JV Lyons Scott R SR Lynch Andy G AG O'Neill Cormac C Zecchini Vincent R VR Rennie Paul S PS Baniahmad Aria A Tavaré Simon S Mills Ian G IG Galanty Yaron Y Crosetto Nicola N Schultz Niklas N Neal David D Helleday Thomas T
Nature communications 20170829 1
Emerging data demonstrate homologous recombination (HR) defects in castration-resistant prostate cancers, rendering these tumours sensitive to PARP inhibition. Here we demonstrate a direct requirement for the androgen receptor (AR) to maintain HR gene expression and HR activity in prostate cancer. We show that PARP-mediated repair pathways are upregulated in prostate cancer following androgen-deprivation therapy (ADT). Furthermore, upregulation of PARP activity is essential for the survival of p ...[more]