Ontology highlight
ABSTRACT:
SUBMITTER: Capitanio D
PROVIDER: S-EPMC5575144 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Capitanio Daniele D Fania Chiara C Torretta Enrica E Viganò Agnese A Moriggi Manuela M Bravatà Valentina V Caretti Anna A Levett Denny Z H DZH Grocott Michael P W MPW Samaja Michele M Cerretelli Paolo P Gelfi Cecilia C
Scientific reports 20170829 1
In mammals, hypoxic stress management is under the control of the Hypoxia Inducible Factors, whose activity depends on the stabilization of their labile α subunit. In particular, the skeletal muscle appears to be able to react to changes in substrates and O<sub>2</sub> delivery by tuning its metabolism. The present study provides a comprehensive overview of skeletal muscle metabolic adaptation to hypoxia in mice and in human subjects exposed for 7/9 and 19 days to high altitude levels. The inves ...[more]