Ontology highlight
ABSTRACT:
SUBMITTER: Sato K
PROVIDER: S-EPMC5575776 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Sato Kazuhide K Nagaya Tadanobu T Nakamura Yuko Y Harada Toshiko T Nani Roger R RR Shaum James B JB Gorka Alexander P AP Kim Insook I Paik Chang H CH Choyke Peter L PL Schnermann Martin J MJ Kobayashi Hisataka H
Molecular pharmaceutics 20150818 9
Near-infrared (NIR) fluorophores have several advantages over visible-light fluorophores, including superior tissue penetration and lower autofluorescence. We recently accessed a new class of readily synthesized NIR cyanines containing a novel C4'-O-alkyl linker, which provides both high chemical stability and excellent optical properties. In this study, we provide the first in vivo analysis of this new class of compounds, represented by the tetrasulfonate FNIR-774 (Frederick NIR 774). Monoclona ...[more]