Dual-targeted anti-TB/anti-HIV heterodimers.
Ontology highlight
ABSTRACT:
SUBMITTER: Alexandrova L
PROVIDER: S-EPMC5576140 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Publications
Dual-targeted anti-TB/anti-HIV heterodimers.
Alexandrova Liudmila L Zicari Sonia S Matyugina Elena E Khandazhinskaya Anastasia A Smirnova Tatiana T Andreevskaya Sofya S Chernousova Larisa L Vanpouille Christophe C Kochetkov Sergei S Margolis Leonid L
Antiviral research 20170722
HIV and M. tuberculosis are two intersecting epidemics making the search for new dual action drugs against both pathogens extremely important. Here, we report on the synthesis and suppressive activities of five dual-targeted HIV/TB compounds. These compounds are heterodimers of AZT, as anti-HIV molecules, and 5-substituted uracil derivatives, as anti-TB molecules. We found that these compounds inhibit the growth of M. tuberculosis and suppress the replication of HIV in human cell cultures and hu ...[more]
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