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Effects of Angelica dahurica and Rheum officinale Extracts on Excisional Wound Healing in Rats.


ABSTRACT: The main objective of wound treatments is to restore the functional skin properties and prevent infection. Traditional Chinese medicine provides alternative anti-inflammatory, antimicrobial, and wound healing therapies. Both Angelica dahurica extract (AE) and Rheum officinale extract (RE) possess antimicrobial activity. In this study, AE and RE were applied in wound treatment to investigate their healing effects. Thirty Sprague-Dawley rats with dorsal full-thickness skin excision were divided into normal saline (NS), AE, RE, AE plus RE (ARE), and Biomycin (BM) groups. The treatment and area measurement of wounds were applied daily for 21 days. Wound biopsies and blood samples were obtained for histology examinations and cytokine analysis. Results showed that wound contraction in ARE group was significantly higher than that in NS and BM groups (P < 0.05). Histological analysis showed that more inflammatory cell infiltration, collagen fibers, and myofibroblasts were observed in ARE treated group than those in NS group on days 3-5. In ARE group, plasma IL-6 levels were elevated during days 3-5 (P > 0.05), and plasma TGF-?1 levels were significantly lower than those in the NS group on days 3-4 (P < 0.05). In conclusion, ARE accelerates wound healing during inflammation and proliferation phases.

SUBMITTER: Yang WT 

PROVIDER: S-EPMC5576423 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Effects of <i>Angelica dahurica</i> and <i>Rheum officinale</i> Extracts on Excisional Wound Healing in Rats.

Yang Wan-Ting WT   Ke Chun-Yen CY   Wu Wen-Tien WT   Harn Horng-Jyh HJ   Tseng Yi-Hsiung YH   Lee Ru-Ping RP  

Evidence-based complementary and alternative medicine : eCAM 20170816


The main objective of wound treatments is to restore the functional skin properties and prevent infection. Traditional Chinese medicine provides alternative anti-inflammatory, antimicrobial, and wound healing therapies. Both <i>Angelica dahurica</i> extract (AE) and <i>Rheum officinale</i> extract (RE) possess antimicrobial activity. In this study, AE and RE were applied in wound treatment to investigate their healing effects. Thirty Sprague-Dawley rats with dorsal full-thickness skin excision w  ...[more]

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