N-arachidonoyl glycine, another endogenous agonist of GPR55.
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ABSTRACT:
SUBMITTER: Console-Bram L
PROVIDER: S-EPMC5576593 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
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N-arachidonoyl glycine, another endogenous agonist of GPR55.
Console-Bram Linda L Ciuciu Sandra M SM Zhao Pingwei P Zipkin Robert E RE Brailoiu Eugen E Abood Mary E ME
Biochemical and biophysical research communications 20170708 4
Interest in lipoamino acids as endogenous modulators of G-protein coupled receptors has escalated due to their involvement in a variety of physiologic processes. In particular, a role for these amino acid conjugates has emerged in the endocannabinoid system. The study presented herein investigated the effects of N-arachidonoyl glycine (NAGly) on a candidate endocannabinoid receptor, GPR55. Our novel findings reveal that NAGly induces concentration dependent increases in calcium mobilization and ...[more]
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