Ontology highlight
ABSTRACT:
SUBMITTER: Lu H
PROVIDER: S-EPMC5576896 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Lu Huiming H Shamanna Raghavendra A RA Keijzers Guido G Anand Roopesh R Rasmussen Lene Juel LJ Cejka Petr P Croteau Deborah L DL Bohr Vilhelm A VA
Cell reports 20160616 1
The RecQ helicase RECQL4, mutated in Rothmund-Thomson syndrome, regulates genome stability, aging, and cancer. Here, we identify a crucial role for RECQL4 in DNA end resection, which is the initial and an essential step of homologous recombination (HR)-dependent DNA double-strand break repair (DSBR). Depletion of RECQL4 severely reduces HR-mediated repair and 5' end resection in vivo. RECQL4 physically interacts with MRE11-RAD50-NBS1 (MRN), which senses DSBs and initiates DNA end resection with ...[more]