Ontology highlight
ABSTRACT:
SUBMITTER: Jayne DRW
PROVIDER: S-EPMC5576933 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Jayne David R W DRW Bruchfeld Annette N AN Harper Lorraine L Schaier Matthias M Venning Michael C MC Hamilton Patrick P Burst Volker V Grundmann Franziska F Jadoul Michel M Szombati István I Tesař Vladimír V Segelmark Mårten M Potarca Antonia A Schall Thomas J TJ Bekker Pirow P
Journal of the American Society of Nephrology : JASN 20170411 9
Alternative C activation is involved in the pathogenesis of ANCA-associated vasculitis. However, glucocorticoids used as treatment contribute to the morbidity and mortality of vasculitis. We determined whether avacopan (CCX168), an orally administered, selective C5a receptor inhibitor, could replace oral glucocorticoids without compromising efficacy. In this randomized, placebo-controlled trial, adults with newly diagnosed or relapsing vasculitis received placebo plus prednisone starting at 60 m ...[more]