Ontology highlight
ABSTRACT:
SUBMITTER: Moffett HF
PROVIDER: S-EPMC5577173 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Moffett H F HF Coon M E ME Radtke S S Stephan S B SB McKnight L L Lambert A A Stoddard B L BL Kiem H P HP Stephan M T MT
Nature communications 20170830 1
Therapies based on immune cells have been applied for diseases ranging from cancer to diabetes. However, the viral and electroporation methods used to create cytoreagents are complex and expensive. Consequently, we develop targeted mRNA nanocarriers that are simply mixed with cells to reprogram them via transient expression. Here, we describe three examples to establish that the approach is simple and generalizable. First, we demonstrate that nanocarriers delivering mRNA encoding a genome-editin ...[more]