Ontology highlight
ABSTRACT:
SUBMITTER: Gharibi A
PROVIDER: S-EPMC5577248 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Gharibi Armen A La Kim Sa S Molnar Justin J Brambilla Daniel D Adamian Yvess Y Hoover Malachia M Hong Julie J Lin Joy J Wolfenden Laurelin L Kelber Jonathan A JA
Scientific reports 20170830 1
Pancreatic ductal adenocarcinoma (PDAC) has single-digit 5-year survival rates at <7%. There is a dire need to improve pre-malignant detection methods and identify new therapeutic targets for abrogating PDAC progression. To this end, we mined our previously published pseudopodium-enriched (PDE) protein/phosphoprotein datasets to identify novel PDAC-specific biomarkers and/or therapeutic targets. We discovered that integrin alpha 1 (ITGA1) is frequently upregulated in pancreatic cancers and assoc ...[more]