Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC5577530 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Li Yonghui Y Ning Qiaoyang Q Shi Jinlong J Chen Yang Y Jiang Mengmeng M Gao Li L Huang Wenrong W Jing Yu Y Huang Sai S Liu Anqi A Hu Zhirui Z Liu Daihong D Wang Lili L Nervi Clara C Dai Yun Y Zhang Michael Q MQ Yu Li L
EMBO molecular medicine 20170701 7
DNA methylation patterns are frequently deregulated in t(8;21) acute myeloid leukaemia (AML), but little is known of the mechanisms by which specific gene sets become aberrantly methylated. Here, we found that the promoter DNA methylation signature of t(8;21)<sup>+</sup> AML blasts differs from that of t(8;21)<sup>-</sup> AMLs. This study demonstrated that a novel hypermethylated zinc finger-containing protein, THAP10, is a target gene and can be epigenetically suppressed by AML1-ETO at the tran ...[more]