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Two Furanosesterterpenoids from the Sponge Luffariella variabilis.

ABSTRACT: Two new sesterterpenoids, 1 and 2, were isolated from the sponge Luffariella variabilis. Their planar structures were characterized with spectroscopic analyses. The sole chiral center of compound 1 was elucidated as 12R by comparing observed and calculated optical rotation values. The configurations of compound 2 were determined by NMR and electronic circular dichroism (ECD) studies. Furthermore, compound 2 showed cytotoxicity at IC₅₀ 1.0 µM against NBT-T2 cells.

SUBMITTER: Ahmadi P

PROVIDER: S-EPMC5577604 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Two Furanosesterterpenoids from the Sponge Luffariella variabilis.

Ahmadi Peni P Higashi Masahiro M Voogd Nicole J de NJ Tanaka Junichi J

Marine drugs 20170810 8

Two new sesterterpenoids, 1 and 2, were isolated from the sponge Luffariella variabilis. Their planar structures were characterized with spectroscopic analyses. The sole chiral center of compound 1 was elucidated as 12R by comparing observed and calculated optical rotation values. The configurations of compound 2 were determined by NMR and electronic circular dichroism (ECD) studies. Furthermore, compound 2 showed cytotoxicity at IC50 1.0 µM against NBT-T2 ...[more]

PMID: 28796183

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