Quantitation of Cancer Treatment Response by ¹⁸F-FDG PET/CT: Multicenter Assessment of Measurement Variability.

ABSTRACT: The aim of this study was to assess the interobserver variability of quantitative ¹⁸F-FDG PET/CT parameters used in assessments of treatment response across multiple sites and readers. Methods: Paired pre- and posttreatment ¹⁸F-FDG PET/CT images of 30 oncologic patients were distributed to 22 readers across 15 U.S. and international sites. One reader was aware of the full medical history (read_reference) of the patients, whereas the 21 other readers were unaware. The readers selected the single hottest tumor from each study, and made SUV measurements from this target lesion and the liver. Descriptive statistics, percentage changes in the measurements, and their agreements were obtained. Results: The intraclass correlation coefficient for the pe

SUBMITTER: O JH 

PROVIDER: S-EPMC5577628 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature