Unknown

Dataset Information

0

Predicting death over 8 years in a prospective cohort of HIV-infected women: the Women's Interagency HIV Study.


ABSTRACT: OBJECTIVES:Predicting mortality in middle-aged HIV-infected (HIV+) women on antiretroviral therapies (ART) is important for understanding the impact of HIV infection. Several health indices have been used to predict mortality in women with HIV infection. We evaluated: (1) an HIV biological index, Veterans Aging Cohort Study (VACS); (2) a physical index, Fried Frailty Index (FFI); and (3) a mental health index, Center for Epidemiologic Studies-Depression (CES-D). Proportional hazards regression analyses were used to predict death and included relevant covariates. DESIGN:Prospective, observational cohort. SETTING:Multicentre, across six sites in the USA. PARTICIPANTS:1385 multirace/ethnic ART-experienced HIV+ women in 2005. PRIMARY AND SECONDARY OUTCOMES:All deaths, AIDS deaths and non-AIDS deaths up to ~8 years from baseline. RESULTS:Included together in one model, VACS Index was the dominant, significant independent predictor of all deaths within 3 years (HR=2.20, 95%?CI 1.83, 2.65, ?2=69.04, p<0.0001), and later than 3 years (HR=1.55, 95%?CI 1.30, 1.84, ?2=23.88, p<0.0001); followed by FFI within 3 years (HR=2.06, 95%?CI 1.19, 3.57, ?2=6.73, p=0.01) and later than 3 years (HR=2.43, 95%?CI 1.58, 3.75, ?2=16.18, p=0.0001). CES-D score was not independently associated with mortality. CONCLUSIONS AND RELEVANCE:This is the first simultaneous evaluation of three common health indices in HIV+ adults. Indices reflecting physical and biological ageing were associated with death.

SUBMITTER: Gustafson DR 

PROVIDER: S-EPMC5577878 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

altmetric image

Publications

Predicting death over 8 years in a prospective cohort of HIV-infected women: the Women's Interagency HIV Study.

Gustafson Deborah R DR   Shi Qiuhu Q   Holman Susan S   Minkoff Howard H   Cohen Mardge H MH   Plankey Michael W MW   Havlik Richard R   Sharma Anjali A   Gange Stephen S   Gandhi Monica M   Milam Joel J   Hoover Donald R DR  

BMJ open 20170630 6


<h4>Objectives</h4>Predicting mortality in middle-aged HIV-infected (HIV+) women on antiretroviral therapies (ART) is important for understanding the impact of HIV infection. Several health indices have been used to predict mortality in women with HIV infection. We evaluated: (1) an HIV biological index, Veterans Aging Cohort Study (VACS); (2) a physical index, Fried Frailty Index (FFI); and (3) a mental health index, Center for Epidemiologic Studies-Depression (CES-D). Proportional hazards regr  ...[more]

Similar Datasets

| S-EPMC3692572 | biostudies-literature
| S-EPMC6007350 | biostudies-literature
| S-EPMC3965606 | biostudies-literature
| S-EPMC5110037 | biostudies-literature
| S-EPMC4335997 | biostudies-literature
| S-EPMC5497768 | biostudies-other
| S-EPMC3652915 | biostudies-literature
| PRJNA422329 | ENA
| PRJNA422330 | ENA
| S-EPMC5408307 | biostudies-literature