Ontology highlight
ABSTRACT:
SUBMITTER: Abdul-Ghani MA
PROVIDER: S-EPMC5577982 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Abdul-Ghani M A MA Puckett C C Triplitt C C Maggs D D Adams J J Cersosimo E E DeFronzo R A RA
Diabetes, obesity & metabolism 20150107 3
<h4>Aim</h4>To test our hypothesis that initiating therapy with a combination of agents known to improve insulin secretion and insulin sensitivity in subjects with new-onset diabetes would produce greater, more durable reduction in glycated haemoglobin (HbA1c) levels, while avoiding hypoglycaemia and weight gain, compared with sequential addition of agents that lower plasma glucose but do not correct established pathophysiological abnormalities.<h4>Methods</h4>Drug-naïve, recently diagnosed subj ...[more]