Ontology highlight
ABSTRACT:
SUBMITTER: Truong XT
PROVIDER: S-EPMC5578196 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Truong Xuan T XT Park Seo-Hee SH Lee Yu-Geon YG Jeong Hang Yeon HY Moon Jae-Hak JH Jeon Tae-Il TI
International journal of molecular sciences 20170821 8
Despite the critical role of melanin in the protection of skin against UV radiation, excess production of melanin can lead to hyperpigmentation and skin cancer. Pear fruits are often used in traditional medicine for the treatment of melasma; therefore, we investigated the effects of pear extract (PE) and its component, protocatechuic acid (PCA), on melanogenesis in mouse melanoma cells. We found that PE and PCA significantly suppressed melanin content and cellular tyrosinase activity through a d ...[more]