Ontology highlight
ABSTRACT:
SUBMITTER: Krebs MP
PROVIDER: S-EPMC5578669 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Krebs Mark P MP Collin Gayle B GB Hicks Wanda L WL Yu Minzhong M Charette Jeremy R JR Shi Lan Ying LY Wang Jieping J Naggert Jürgen K JK Peachey Neal S NS Nishina Patsy M PM
PloS one 20170831 8
Mouse models provide a valuable tool for exploring pathogenic mechanisms underlying inherited human disease. Here, we describe seven mouse models identified through the Translational Vision Research Models (TVRM) program, each carrying a new allele of a gene previously linked to retinal developmental and/or degenerative disease. The mutations include four alleles of three genes linked to human nonsyndromic ocular diseases (Aipl1tvrm119, Aipl1tvrm127, Rpgrip1tvrm111, RhoTvrm334) and three alleles ...[more]