Dataset Information

Bone health and HIV in resource-limited settings: a scoping review.

ABSTRACT:

Purpose of review

Sub-Saharan Africa and other resource-limited settings (RLS) bear the greatest burden of the HIV epidemic globally. Advantageously, the expanding access to antiretroviral therapy (ART) has resulted in increased survival of HIV individuals in the last 2 decades. Data from resource rich settings provide evidence of increased risk of comorbid conditions such as osteoporosis and fragility fractures among HIV-infected populations. We provide the first review of published and presented data synthesizing the current state of knowledge on bone health and HIV in RLS.

Recent findings

With few exceptions, we found a high prevalence of low bone mineral density (BMD) and hypovitaminosis D among HIV-infected populations in both RLS and resource rich settings. Although most recognized risk factors for bone loss are similar across settings, in certain RLS there is a high prevalence of both non-HIV-specific risk factors and HIV-specific risk factors, including advanced HIV disease and widespread use of ART, including tenofovir disoproxil fumarate, a non-BMD sparing ART. Of great concern, we neither found published data on the effect of tenofovir disoproxil fumarate initiation on BMD, nor any data on incidence and prevalence of fractures among HIV-infected populations in RLS.

Summary

To date, the prevalence and squeal of metabolic bone diseases in RLS are poorly described. This review highlights important gaps in our knowledge about HIV-associated bone health comorbidities in RLS. This creates an urgent need for targeted research that can inform HIV care and management guidelines in RLS.

SUBMITTER: Matovu FK

PROVIDER: S-EPMC5578733 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Publications

Bone health and HIV in resource-limited settings: a scoping review.

Matovu Flavia Kiweewa FK Wattanachanya Lalita L Beksinska Mags M Pettifor John M JM Ruxrungtham Kiat K

Current opinion in HIV and AIDS 20160501 3

<h4>Purpose of review</h4>Sub-Saharan Africa and other resource-limited settings (RLS) bear the greatest burden of the HIV epidemic globally. Advantageously, the expanding access to antiretroviral therapy (ART) has resulted in increased survival of HIV individuals in the last 2 decades. Data from resource rich settings provide evidence of increased risk of comorbid conditions such as osteoporosis and fragility fractures among HIV-infected populations. We provide the first review of published and ...[more]

PMID: 27023284

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Dataset Information

Bone health and HIV in resource-limited settings: a scoping review.

Purpose of review

Recent findings

Summary

Publications

Bone health and HIV in resource-limited settings: a scoping review.

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