Ontology highlight
ABSTRACT:
SUBMITTER: Smith AJ
PROVIDER: S-EPMC5578736 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Smith Alex J AJ Yao Xiaoming X Dix James A JA Jin Byung-Ju BJ Verkman Alan S AS
eLife 20170821
Transport of solutes through brain involves diffusion and convection. The importance of convective flow in the subarachnoid and paravascular spaces has long been recognized; a recently proposed 'glymphatic' clearance mechanism additionally suggests that aquaporin-4 (AQP4) water channels facilitate convective transport through brain parenchyma. Here, the major experimental underpinnings of the glymphatic mechanism were re-examined by measurements of solute movement in mouse brain following intrac ...[more]