Ontology highlight
ABSTRACT:
SUBMITTER: Zhang P
PROVIDER: S-EPMC5578964 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Zhang Ping P Liu Yunsong Y Wang Yuejun Y Zhang Min M Lv Longwei L Zhang Xiao X Zhou Yongsheng Y
Scientific reports 20170831 1
SIRT6 has been identified as an H3K9 deacetylase and a critical regulator of genome stability, telomere integrity, and metabolic homeostasis. Sirt6-deficient mice displayed dramatic phenotypes including profound lymphopenia, loss of subcutaneous fat, lordokyphosis and low bone marrow density. Here, we report that SIRT6 regulates osteogenic differentiation independent of its deacetylase activity in vitro. Further mechanistic studies showed that SIRT6 involves the cell fate determination by modula ...[more]