Ontology highlight
ABSTRACT:
SUBMITTER: Lim SY
PROVIDER: S-EPMC5578970 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Lim So-Young SY Macheleidt Iris I Dalvi Priya P Schäfer Stephan C SC Kerick Martin M Ozretić Luka L Ortiz-Cuaran Sandra S George Julie J Merkelbach-Bruse Sabine S Wolf Jürgen J Timmermann Bernd B Thomas Roman K RK Schweiger Michal R MR Buettner Reinhard R Odenthal Margarete M
Scientific reports 20170831 1
The epigenetic writer lysine-specific demethylase 1 (LSD1) is aberrantly upregulated in many cancer types and its overexpression correlates with poor survival and tumor progression. In this study, we analysed LSD1 function in non-small cell lung cancer adenocarcinomas. Expression profiling of 182 cases of lung adenocarcinoma proved a significant correlation of LSD1 overexpression with lung adenocarcinoma progression and metastasis. KRAS-mutated lung cancer cell clones were stably silenced for LS ...[more]