Distinct clinical features between acute and chronic progressive parenchymal neuro-Behcet disease: meta-analysis.

ABSTRACT: Neuro-Behçet's disease (NBD) is subcategorized into parenchymal-NBD (P-NBD) and non-parenchymal-NBD types. Recently, P-NBD has been further subdivided into acute P-NBD (A-P-NBD) and chronic progressive P-NBD (CP-P-NBD). Although an increasing number of studies have reported the various clinical features of A-P-NBD and CP-P-NBD over the last two decades, there was a considerable inconsistency. Two investigators systematically searched four electrical databases to detect studies that provided sufficient data to assess the specific characteristics of A-P-NBD and CP-P-NBD. All meta-analysis was carried out by employing the random-model generic inverse variance method. We included 11 reports consisted of 184 A-P-NBD patients and 114 CP-P-NBD patients. While fever (42% for A-P-NBD, 5% for CP-P-NBD, p?2?=?93%) was more frequently observed in A-P-NBD cases; sphincter disturbances (9%, 34%, P?=?0.005, I²?=?87%), ataxia (16%, 57%, P?2?=?92%), dementia (7%, 61%, P?2?=?97%), confusion (5%, 18%, P?=?0.04, I²?=?76%), brain stem atrophy on MRI (4%, 75%, P?2?=?98%), and abnormal MRI findings in cerebellum (7%, 54%, P?=?0.02, I²?=?81%) were more common in CP-P-NBD. Cerebrospinal fluid cell count (94/mm³, 11/mm³, P?=?0.009, I²?=?85%) was higher in A-P-NBD cases. We demonstrated that A-P-NBD and CP-P-NBD had clearly different clinical features and believe that these data will help future studies investigating P-NBD.

SUBMITTER: Ishido M 

PROVIDER: S-EPMC5579041 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature