Unknown

Dataset Information

0

FMISO-PET-derived brain oxygen tension maps: application to glioblastoma and less aggressive gliomas.


ABSTRACT: Quantitative imaging modalities for the analysis of hypoxia in brain tumors are lacking. The objective of this study was to generate absolute maps of tissue ptO2 from [18F]-FMISO images in glioblastoma and less aggressive glioma patients in order to quantitatively assess tumor hypoxia. An ancillary objective was to compare estimated ptO2 values to other biomarkers: perfusion weighted imaging (PWI) and tumor metabolism obtained from 1H-MR mono-voxel spectroscopy (MRS). Ten patients with glioblastoma (GBM) and three patients with less aggressive glioma (nGBM) were enrolled. All patients had [18F]-FMISO and multiparametric MRI (anatomic, PWI, MRS) scans. A non-linear regression was performed to generate ptO2 maps based on normal appearing gray (NAGM) and white matter (NAWM) for each patient. As expected, a marked [18F]-FMISO uptake was observed in GBM patients. The ptO2 based on patient specific calculations was notably low in this group (4.8?±?1.9?mmHg, p?

SUBMITTER: Chakhoyan A 

PROVIDER: S-EPMC5579277 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications


Quantitative imaging modalities for the analysis of hypoxia in brain tumors are lacking. The objective of this study was to generate absolute maps of tissue p<sub>t</sub>O<sub>2</sub> from [<sup>18</sup>F]-FMISO images in glioblastoma and less aggressive glioma patients in order to quantitatively assess tumor hypoxia. An ancillary objective was to compare estimated p<sub>t</sub>O<sub>2</sub> values to other biomarkers: perfusion weighted imaging (PWI) and tumor metabolism obtained from <sup>1</s  ...[more]

Similar Datasets

| S-EPMC5065740 | biostudies-literature
| S-EPMC6526364 | biostudies-literature
| S-EPMC8027395 | biostudies-literature
| S-EPMC6910644 | biostudies-literature
| S-EPMC9564145 | biostudies-literature
| S-EPMC2702690 | biostudies-literature
| S-EPMC2733881 | biostudies-literature
| S-EPMC6114038 | biostudies-literature
| S-EPMC9179546 | biostudies-literature
| S-EPMC6199734 | biostudies-literature