Ontology highlight
ABSTRACT:
SUBMITTER: Li W
PROVIDER: S-EPMC5579362 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Li Wenjing W Yi Peishan P Zhu Zhiwen Z Zhang Xianliang X Li Wei W Ou Guangshuo G
The EMBO journal 20170725 17
Neuronal cilia that are formed at the dendritic endings of sensory neurons are essential for sensory perception. However, it remains unclear how the centriole-derived basal body is positioned to form a template for cilium formation. Using fluorescence time-lapse microscopy, we show that the centriole translocates from the cell body to the dendrite tip in the <i>Caenorhabditis elegans</i> sensory neurons. The centriolar protein SAS-5 interacts with the dynein light-chain LC8 and conditional mutat ...[more]