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Considerations in the Development of Reversibly Binding PET Radioligands for Brain Imaging.

ABSTRACT: The development of reversibly binding radioligands for imaging brain proteins in vivo, such as enzymes, neurotransmitter transporters, receptors and ion channels, with positron emission tomography (PET) is keenly sought for biomedical studies of neuropsychiatric disorders and for drug discovery and development, but is recognized as being highly challenging at the medicinal chemistry level. This article aims to compile and discuss the main considerations to be taken into account by chemists embarking on programs of radioligand development for PET imaging of brain protein targets.

SUBMITTER: Pike VW

PROVIDER: S-EPMC5579844 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Considerations in the Development of Reversibly Binding PET Radioligands for Brain Imaging.

Pike Victor W VW

Current medicinal chemistry 20160101 18

The development of reversibly binding radioligands for imaging brain proteins in vivo, such as enzymes, neurotransmitter transporters, receptors and ion channels, with positron emission tomography (PET) is keenly sought for biomedical studies of neuropsychiatric disorders and for drug discovery and development, but is recognized as being highly challenging at the medicinal chemistry level. This article aims to compile and discuss the main considerations to be taken into account by chemists embar ...[more]

PMID: 27087244

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Considerations in the Development of Reversibly Binding PET Radioligands for Brain Imaging.

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Considerations in the Development of Reversibly Binding PET Radioligands for Brain Imaging.

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