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Crosslinked shells for nano-assembled capsules: a new encapsulation method for smaller Gd3+-loaded capsules with exceedingly high relaxivities.

ABSTRACT: Nano-assembled capsules can incorporate large payloads of high relaxivity Gd3+, permitting the development of highly detectable molecular imaging agents for MRI. A new encapsulating shell, based upon cross-linked peptides, is found to afford smaller capsules (127 nm average diameter) with exceptionally high per-Gd3+ relaxivities (70.7 s-1 mmolal-1).

SUBMITTER: Farashishiko A

PROVIDER: S-EPMC5580261 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Crosslinked shells for nano-assembled capsules: a new encapsulation method for smaller Gd3+-loaded capsules with exceedingly high relaxivities.

Farashishiko Annah A Plush Sally E SE Maier Karley B KB Dean Sherry A A Woods Mark M

Chemical communications (Cambridge, England) 20170601 47

Nano-assembled capsules can incorporate large payloads of high relaxivity Gd3+, permitting the development of highly detectable molecular imaging agents for MRI. A new encapsulating shell, based upon cross-linked peptides, is found to afford smaller capsules (127 nm average diameter) with exceptionally high per-Gd3+ relaxivities (70.7 s-1 mmolal-1). ...[more]

PMID: 28555682

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