Ontology highlight
ABSTRACT:
SUBMITTER: Dai C
PROVIDER: S-EPMC5580512 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Dai Charles C Heemers Hannelore H Sharifi Nima N
Cold Spring Harbor perspectives in medicine 20170901 9
The androgen-signaling axis plays a pivotal role in the pathogenesis of prostate cancer. Since the landmark discovery by Huggins and Hodges, gonadal depletion of androgens has remained a mainstay of therapy for advanced disease. However, progression to castration-resistant prostate cancer (CRPC) typically follows and is largely the result of restored androgen signaling. Efforts to understand the mechanisms behind CRPC have revealed new insights into dysregulated androgen signaling and intratumor ...[more]