Dataset Information

Porous Polyurethane Foam for Use as a Particle Collection Substrate in a Nanoparticle Respiratory Deposition Sampler.

ABSTRACT: Porous polyurethane foam was evaluated to replace the eight nylon meshes used as a substrate to collect nanoparticles in the Nanoparticle Respiratory Deposition (NRD) sampler. Cylindrical (25-mm diameter by 40-mm deep) foam with 110 pores per inch was housed in a 25-mm-diameter conductive polypropylene cassette cowl compatible with the NRD sampler. Pristine foam and nylon meshes were evaluated for metals content via elemental analysis. The size-selective collection efficiency of the foam was evaluated using salt (NaCl) and metal fume aerosols in independent tests. Collection efficiencies were compared to the nanoparticulate matter (NPM) criterion and a semi-empirical model for foam. Changes in collection efficiency and pressure drop of the foam and nylon meshes were measured after loading with metal fume particles as measures of substrate performance. Substantially less titanium was found in the foam (0.173 ?g sampler-1) compared to the nylon mesh (125 ?g sampler-1), improving the detection capabilities of the NRD sampler for titanium dioxide particles. The foam collection efficiency was similar to that of the nylon meshes and the NPM criterion (R2 = 0.98, for NaCl), although the semi-empirical model underestimated the experimental efficiency (R2 = 0.38). The pressure drop across the foam was 8% that of the nylon meshes when pristine and changed minimally with metal fume loading (~ 19 mg). In contrast, the pores of the nylon meshes clogged after loading with ~ 1 mg metal fume. These results indicate that foam is a suitable substrate to collect metal (except for cadmium) nanoparticles in the NRD sampler.

SUBMITTER: Mines LWD

PROVIDER: S-EPMC5580938 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Porous Polyurethane Foam for Use as a Particle Collection Substrate in a Nanoparticle Respiratory Deposition Sampler.

Mines Levi W D LWD Park Jae Hong JH Mudunkotuwa Imali A IA Anthony T Renée TR Grassian Vicki H VH Peters Thomas M TM

Aerosol science and technology : the journal of the American Association for Aerosol Research 20160316 5

Porous polyurethane foam was evaluated to replace the eight nylon meshes used as a substrate to collect nanoparticles in the Nanoparticle Respiratory Deposition (NRD) sampler. Cylindrical (25-mm diameter by 40-mm deep) foam with 110 pores per inch was housed in a 25-mm-diameter conductive polypropylene cassette cowl compatible with the NRD sampler. Pristine foam and nylon meshes were evaluated for metals content via elemental analysis. The size-selective collection efficiency of the foam was eva ...[more]

PMID: 28867869

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Project description:BACKGROUND:Although nanoparticles and their hazardous effects on human health are well elucidated meanwhile, inhalation and distribution of these materials in the human respiratory tract still represent partly enigmatic phenomena. Main objective of the present study was the detailed description of a mathematical method, with the help of which spatial distributions of nanoparticles deposited in the tracheobronchial tree may be visualized appropriately. METHODS:The technique is founded on a stochastic model of the bronchial network, within which inhaled particles follow individual, randomly selected trajectories. The lengths of these random paths depend on the airway-specific deposition probabilities calculated for the particles and the duration of the breath cycle. Positions of the deposited material were determined by computation of the exact lengths of individual particle trajectories and the orientation of single path segments within a Cartesian coordinate system, where the z-direction corresponds with the trachea. For a better quantification of the particle distribution and its eventual comparison with experimental data particle coordinates were fitted into a voxel grid [1 voxel = (0.467 cm)(3)]. Particle deposition is chiefly controlled by diffusive processes, whereas deposition mechanisms associated with inertia or gravity play a subordinate role. RESULTS:Deposition patterns were visualized for particles with sizes of 1, 10, and 100 nm. As clearly demonstrated by the results obtained from the modeling procedure, under normal breathing conditions 1-nm particles tend to deposit in the upper airways, whilst 10- and 100-nm particles are preferably accumulated in the airways of the central and peripheral lung. The particle dose deposited in the extrathoracic and thoracic airways within one breath cycle significantly declines with increasing particle size. CONCLUSIONS:Based on the predictions presented in this study possible consequences of nanoparticle inhalation to the health of subjects increasingly exposed to these airborne materials were discussed.

Dataset Information

Porous Polyurethane Foam for Use as a Particle Collection Substrate in a Nanoparticle Respiratory Deposition Sampler.

Publications

Porous Polyurethane Foam for Use as a Particle Collection Substrate in a Nanoparticle Respiratory Deposition Sampler.

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